When symptoms don’t have a clear answer
Understand your genetic risk for celiac disease
Gain insight into your genetic predisposition to celiac disease without prolonged gluten exposure or invasive testing. A simple first step to gain clarity when symptoms are unclear.
Get clarity on your celiac risk
Saliva-based test, suitable for adults and children
Results within approximately 2 to 4 weeks
No gluten exposure required
No biopsy or hospital visits
Celiac disease can be difficult to detect
For many people, the path to a celiac disease diagnosis involves long periods of non-specific symptoms, uncertainty, and repeated testing. Traditional investigations may require continued gluten consumption despite symptoms and sometimes invasive procedures such as biopsies.
This test analyses genetic predisposition to celiac disease through HLA typing, the same type of genetic analysis used in healthcare to assess genetic risk associated with the condition.
Because the test analyses genetic markers, you do not need to consume gluten before testing. The sample is collected easily at home using saliva and sent to a laboratory for analysis. The results may provide clearer insight for further medical evaluation or discussions with healthcare professionals.
Why celiac disease is often difficult to identify
For many, the question is simple:
Could gluten be contributing to the symptoms or not?
Digestive symptoms, fatigue, and nutrient deficiencies can have many causes. In some cases, celiac disease is considered but diagnosing it is not always straightforward.
Traditional testing often requires consuming gluten over time, which can be uncomfortable or impractical, especially if you have already adjusted your diet.
This test may be relevant if you:
- Have unexplained digestive symptoms or ongoing discomfort
- Want to rule out celiac disease quickly
- Are already avoiding gluten but still lack clear answers
- Want to avoid unnecessary tests or prolonged investigations
- Have a close relative diagnosed with celiac disease
- Have received inconclusive or unclear test results
Your HLA type is unique, and clinically relevant
HLA (Human Leukocyte Antigens) are proteins found on the surface of most cells in the body. They act as a biological identification system, helping the immune system distinguish between the body’s own cells and foreign substances. Your HLA type is inherited from your parents. You receive half of your HLA markers from your mother and half from your father, creating a unique genetic combination that acts as a biological identity for your immune system.
This system helps the body distinguish between its own cells and foreign substances, such as viruses, bacteria, or transplanted tissue.
Because of this, HLA plays a central role in several areas of medicine. In transplantation, a high degree of matching between donor and recipient is required to reduce the risk of rejection. In other cases, certain HLA types are associated with an increased or decreased risk of developing specific conditions, particularly autoimmune diseases.
Celiac disease is one of the conditions most strongly linked to specific HLA variants, primarily HLA-DQ2 and HLA-DQ8. At the same time, these variants are relatively common in the general population, meaning that many people carry them without ever developing the disease.
This is why HLA analysis is used to assess whether a condition is likely or unlikely, rather than to confirm a diagnosis.
HLA typing is also relevant in a broader medical context. Certain variants have been associated with conditions such as ankylosing spondylitis, Behçet’s disease, narcolepsy, and rare eye conditions. For some conditions, the clinical relevance is well established, while for others, the relationship is more complex.
Understanding your HLA type can provide valuable medical insight that may be relevant throughout life.
See how the test works
The genetic link behind celiac disease
Celiac disease is an autoimmune condition in which the immune system reacts to proteins in certain grains, primarily gluten. This reaction causes inflammation in the small intestine and can impair the body’s ability to absorb nutrients.
With a gluten-free diet, the inflammation typically resolves and the intestinal lining can recover.
What makes celiac disease unique is its strong genetic link.
Almost all individuals with celiac disease carry specific HLA gene variants, primarily HLA-DQ2 and HLA-DQ8. Approximately 95% of patients are positive for HLA-DQ2, and most of the remaining cases carry HLA-DQ8.
If these HLA markers (DQ2 or DQ8) are not present, the risk of celiac disease is very low.
These genetic variants are relatively common in the population, which means many people carry them without developing the disease.
This is why HLA testing is used to determine whether celiac disease is likely or unlikely, rather than to confirm a diagnosis.
How the test works
From order to answer, the process is simple and fully handled for you.
Delivered to your home
Order your test kit online and receive everything you need, ready to use
Take your sample
A quick cheek swab, no preparation or dietary changes required
Laboratory analysis
Your DNA is analysed using validated, clinically established methods
Get your results
A clear answer within approximately 2–4 weeks
This test analyses specific HLA genes associated with celiac disease. Almost all individuals with celiac disease carry the genetic variants HLA-DQ2 or HLA-DQ8.
If these markers are not present, celiac disease is considered highly unlikely.
No gluten exposure required
You can take the test regardless of your current diet
Helps rule out celiac disease
Absence of key markers makes the diagnosis highly unlikely
Simple saliva test
Collected at home, non-invasive
Suitable for children and adults
Can be used across the whole family
A first step that can clarify whether further investigation is needed. In clinical practice, further evaluation may include multiple blood tests, extended diagnostic processes over several months, and in some cases intestinal biopsy.
What your results mean
This test does not diagnose celiac disease but provides important genetic information that helps guide further evaluation.
If markers are not detected
Celiac disease can be ruled out with high probability.
Because the vast majority of individuals with celiac disease carry HLA-DQ2 or HLA-DQ8, the absence of these markers means that celiac disease is very unlikely to be the cause of your symptoms.
This does not mean that you have celiac disease.
These genetic variants are relatively common in the population, and many people carry them without ever developing the condition. If markers are present, further clinical evaluation may be recommended to determine whether celiac disease is actually present.
Not comparable to at-home self-tests
Some self-tests for celiac disease available in pharmacies are based on antibody measurements. These tests require active gluten consumption and may show varying reliability, with a risk of both false positive and false negative results.
They do not assess the underlying genetic predisposition.
This test is fundamentally different.
It analyses the specific HLA gene variants (HLA-DQ2 and HLA-DQ8) that are directly linked to celiac disease and used in clinical evaluation according to established guidelines.
This test analyses specific HLA genes associated with celiac disease. Almost all individuals with celiac disease carry the genetic variants HLA-DQ2 or HLA-DQ8.
If these markers are not present, celiac disease can be ruled out with high certainty.
Based on validated laboratory methods
Performed using high-resolution genetic analysis in accredited laboratories
Recommended in clinical guidelines
European guidelines (ESPGHAN) recommend HLA testing in unclear diagnostic cases
No need for gluten exposure
Unlike antibody-based tests, this test can be taken regardless of diet
Reduces uncertainty
Absence of key markers can rule out celiac disease with high certainty
For this reason, HLA testing is used in healthcare as part of a structured diagnostic process, rather than as a standalone consumer test.
Why HLA typing is used in clinical practice
HLA typing is not used to diagnose a disease on its own, but to provide critical genetic information about how your immune system functions and how your body may respond in different medical situations.
This makes it relevant across several areas of medicine and the information is used in clinical practice, to guide medical decisions in situations where immune recognition is critical:
Assessment of disease risk
Certain HLA variants are associated with an increased or decreased risk of developing specific conditions, particularly autoimmune diseases
Celiac disease evaluation (guideline-supported)
European clinical guidelines (ESPGHAN) recommend HLA testing in cases where celiac disease diagnosis is uncertain, for example when biopsy or antibody results are inconclusive
Understanding immune response
Your HLA type influences how your immune system responds to viruses, bacteria, and other external factors, and has been linked in research to differences in disease susceptibility
Transplant matching
HLA typing is used to determine whether a person can safely donate stem cells, bone marrow, or an organ. A higher degree of matching reduces the risk of rejection and improves treatment outcomes
For celiac disease in particular, HLA typing is a well-established tool used to determine whether the condition is likely or unlikely, and whether further clinical investigation is needed.
Celiac Risk & Genetic Analysis
Understand your genetic likelihood of celiac disease, without prolonged gluten exposure or more invasive testing, such as intestinal biopsy.
A simple first step when symptoms don’t have a clear explanation.
Price:
3,700 SEK
